Obesity & Radiation Therapy Outcomes

We have observed clinically that obese patients with cervical cancer have favorable outcomes after chemoradiation therapy (Oncotarget, 2018).  This is unusual because obesity has been associated with not only increased incidence, but also increased treatment-related morbidity and decreased survival outcome for cancers in other sites.  Our clinical data indicates that at least some of these effects are mediated through decreased PI3K/AKT signaling in tumors from obese patients.  Naoshad is currently working hard to identify other potential mechanisms using our preclinical models. Stay tuned!!!!!